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KMID : 0603520000050040199
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Journal of Korean Association of Cancer Prevention
2000 Volume.5 No. 4 p.199 ~ p.208
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The Modifying Effect of Indole-3-carbinol (I3C) and Its Metabolites, Phytochemicals from Cruciferae Vegetables, in Chemical Carcinogenesis and Cancer Prevention
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Kang Jin-Seok
Kim Dae-Joong
Jang Dong-Deuk
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Abstract
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It has been reported that several naturally occurring compounds in fruit and vegetables possess anticarcinogenic properties. Indole-3-carbinol (I3C) is a one of the components in brassica vegetables demonstrating anticarcinogenic potential in experimental animals and humans. I3C and its metabolites such as 3-3’-di-indolymethane (DIM) and indole[3, 2-b] carbazole (ICZ) have been shown to exert cancer chemopreventive effects in liver, colon and mammary tissue when they were applied before or concurrent exposure of carcinogen. The chemopreventive effects were set on to the pathway of aryl hydrocarbon receptor (AHR), cytochrome P450 isoenzymes (CYP) induction and alteration of estrogen metabolism. However, there have been several reports on the clear evidences of tumor promotion in some organs such as liver, colon, thyroid and pancreas etc. I3C and its several metabolites have the action of inducing AHR mediating response and estrogenic effects, so it mean that they may have carcinogenic effect in the condition that initiated cells or tumor cells are growing, especially in high dose treatment. It may be considered that the function of I3C would be different in target organs and the treatment time point before, during and after carcinogen exposure and it is very important to clarify the actions of I3C after carcinogen exposure. We reevaluate the action of I3C in chemical carcinogenesis.
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KEYWORD
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Indole-3-carbinol (I3C), 3-3’-di-indolymethane (DIM), Indole [3, 2-b] carbazole (ICZ), Aryl hydrocarbon receptor (AHR), Cytochrome P450 isoenzymes (CYP), Estrogen
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